Endocrine Abstracts

It is well known that successful treatment of Cushing’s syndrome (CS) leads to transient adrenal insufficiency due to suppression of the hypothalamo–pituitary–adrenal (HPA) axis by the long-standing cortisol excess. Reports on HPA recovery in recent years including CS patients with less florid clinical features are scarce. Herein we report our findings in a series of patients with various forms of CS successfully treated in our department over the last 15 years....

Cushing’s syndrome (CS) is a disease entity that through hypercortisolism affects all body’s tissues leading to increased morbidity, decreased quality of life and mortality. Muscles are among the tissues primarily affected. However, data on the impact of endogenous hypercortisolism on functional muscle capacity and daily physical activity levels are scarce. We studied 23 subjects with endogenous CS (mean age: 40.73±2.17 years) and 22 healthy aged and sex matched...

Generously supported by IPSEN)-->Endogenous hypercortisolism leads to increased morbidity and mortality. As Cushing’s disease (CD) is a rare disorder, data on co-morbidities outcome after current treatment interventions are scarce.We studied 78 patients with CD (67 females, 11 males, mean age 42.2±1.4 years), with a follow up of 90.8±7.8 months. All patients underwent transsphenoidal surgery (TSS...

The aim of the study was to examine the therapeutic trends and the long-term outcome of available therapeutic modalities for acromegaly in a single center over a 40 year period.We retrospectively studied 300 acromegalic patients (131 men, 169 women, 153 macroadenomas and 147 microadenomas) from 1970 until 2010; 154 patients were diagnosed before 1990 (group A) and 146 after 1990 (group B). Outcome was evaluated by IGF1 and GH (random plus post OGTT) meas...